Abstract
We disclose here a new class of kinase inhibitors, obtained by replacing the phenyl ring of a 3-quinolinecarbonitrile system with a thiophene ring. When suitably substituted, the resultant 7-phenylaminothieno[3,2-b]pyridine-6-carbonitrile analogues show potent inhibition of Src kinase activity.
MeSH terms
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Pyridines / chemical synthesis*
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Pyridines / pharmacology
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Structure-Activity Relationship
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
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src-Family Kinases / antagonists & inhibitors*
Substances
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Enzyme Inhibitors
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Pyridines
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Thiophenes
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src-Family Kinases